Forhidrol, a bioactive fraction of Phaleria macrocarpa (Scheff.) Boerl., increases reverse cholesterol transport pathway by down-regulation of cholesteryl ester transfer protein activity
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Stereochemistry of lignans in Phaleria macrocarpa (Scheff.) Boerl.
Phaleria macrocarpa (Scheff.) Boerl., a member of the Thymelaeaceae, is traditionally used in Indonesia as medicinal plant against cancer. In this context, we isolated the lignans pinoresinol, lariciresinol and matairesinol from different parts of this plant. The enantiomeric composition of these lignans was determined by chiral column analysis. Pinoresinol and lariciresinol were mixtures of bo...
متن کاملCholesteryl ester transfer protein inhibition: effect on reverse cholesterol transport?
Statins, inhibitors of the key enzyme in the biosynthesis of cholesterol (ie, 3-hydroxy-3-methylglutaryl [HMG]coenzyme A [CoA] reductase), are widely used as the prevailing strategy to combat atherosclerosis through reducing LDL cholesterol levels. Large-scale clinical trials have shown that statins markedly reduce coronary events.1,2 A meta-analysis of 22 studies enrolling nearly 70 000 indivi...
متن کاملFlavonoid Analyses and Antimicrobial Activity of Various Parts of Phaleria macrocarpa (Scheff.) Boerl Fruit
Phaleria macrocarpa (Scheff.) Boerl (Thymelaceae) is commonly known as 'Crown of God', 'Mahkota Dewa', and 'Pau'. It originates from Papua Island, Indonesia and it grows in tropical areas. Empirically, it is potent in treating the hypertensive, diabetic, cancer and diuretic patients. It has a long history of ethnopharmacological usage, and the lack of information about its biological activities...
متن کاملAntioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds
In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased. Phaleria macrocarpa (Scheff.) Boerl is frequently used in traditional medicine. The present investigation was undertaken with the purpose of developing pharmacopoeial standards for this species. Nutritional values such as ash, fiber, protein, fat, and carbohydrate contents were investig...
متن کامل29-Norcucurbitacin derivatives isolated from the Indonesian medicinal plant, Phaleria macrocarpa (Scheff.) Boerl.
The new 29-norcucurbitacin, desacetylfevicordin A (1), together with three known 29-norcucurbitacin derivatives (2-4) were isolated from seeds of the Indonesian medicinal plant, Phaleria macrocarpa (Scheff.) Boerl. The structures of 1-4 were elucidated on the basis of spectroscopic analyses and chemical transformation. These compounds exhibited toxicity against the brine shrimp (Artemia salina).
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ژورنال
عنوان ژورنال: Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale
سال: 2018
ISSN: 2284-0230,1826-8838
DOI: 10.4081/jbr.2018.6863